Shirley’s Metastatic Lung Cancer Story

At age 34, Shirley, a translator from Southern California, faced the unexpected news that she had stage 4 lung cancer with an ALK mutation.

Shirley’s journey began in 2021, during the height of the COVID-19 pandemic, with a persistent cough that refused to go away despite multiple rounds of antibiotics and testing. Her doctors reassured her it was likely a minor infection, even though her symptoms grew to include severe back pain. Finally, a CT scan revealed a mass, but doctors still downplayed the likelihood of cancer due to her young age and history. Initially undiagnosed, she faced months of additional procedures, including 2 bronchoscopies and a wedge resection surgery. Only after extensive testing did she receive the staggering news: she had adenocarcinoma, initially suspected to have originated elsewhere in her body. Despite various scans showing otherwise, she spent weeks fearing widespread cancer.

Determined to take control, Shirley switched hospitals, explored different insurance options when she got married to her longtime boyfriend, and underwent chemotherapy. The side effects were brutal, including severe hair loss, swallowing difficulties, and infections that required hospitalization. Finally, genetic testing revealed she had an ALK mutation, allowing her to switch to a targeted therapy in pill form, providing 2 years of relative stability and an improved quality of life. Then, in 2023, the cancer began progressing again, necessitating further procedures and consultations. When her initial targeted therapy became ineffective, Shirley bravely enrolled in a clinical trial for a 4th-generation ALK inhibitor in July 2024. This new medication has had minimal side effects, with her tumor currently stable. Although she initially hesitated to join a clinical trial, Shirley realized its promise and now appreciates the thorough monitoring and regular scans.

Living with an incurable cancer has profoundly affected Shirley’s outlook on life. “It feels like I have a bomb inside of me,” she says, expressing the constant awareness of her tumor’s presence. With humor as her coping mechanism, Shirley shares darkly comedic memes and gives villain names to her tumor. Her husband and fellow cancer patients have become her pillars of support, as she finds comfort and laughter within her community of ALK patients, appreciating the unique understanding they bring.

Despite the trials of cancer, Shirley finds solace in sharing her experience, including on her Instagram, to help others. Her advice to newly diagnosed patients is heartfelt: avoid over-Googling statistics and connect with others who understand the cancer journey. “You’re not a statistic,” she insists. “See yourself as an individual.”

Shirley’s journey is one of resilience and transformation, where she now cherishes connections and purpose. By sharing her story, she aims to support others, proving that even amid uncertainty, there is value in embracing life with hope and humor.