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Chemotherapy Domvanalimab fluorouracil 5fu FOLFOX (folinic acid, fluorouracil, oxaliplatin) Immunotherapy nivolumab (Opdivo) Patient Stories Stomach Cancer Treatments Zimberelimab

Melissa’s Stage 4B Stomach Cancer Story

Melissa’s Stage 4B Stomach Cancer Story

Interviewed by: Nikki Murphy
Edited by: Chris Sanchez

Melissa, a resident of Clarksville, TN, was diagnosed with stage 4b metastatic gastric adenocarcinoma, a form of stomach cancer, following a challenging diagnostic process that began in late 2021. After a mild case of COVID-19, she experienced persistent throat discomfort, but initial visits to specialists yielded no conclusive results. Doctors initially attributed her symptoms to acid reflux and anxiety. In September 2022, while vacationing in Mexico, Melissa experienced nausea and vomiting, but she dismissed it, believing it was a urinary tract infection.

Upon Melissa’s return home, her massage therapist noticed something unusual in her back, prompting her to seek further medical evaluation. A proactive primary care physician ordered an ultrasound, revealing gallstones, and Melissa underwent gallbladder surgery. Although she initially felt better, nausea returned, and an endoscopy revealed a paralyzed stomach and, ultimately, a mass near her esophagus. Biopsies confirmed that Melissa had invasive adenocarcinoma, a diagnosis that left her and her family in shock.

In December 2021, Melissa began treatment with FOLFOX chemotherapy and two trial immunotherapy drugs, zimberelimab and domvanalimab. Despite an initial prognosis that gave her less than a year to live, Melissa responded remarkably well to treatment. By April 2023, her scans showed no evidence of disease, an unexpected outcome given the aggressive nature of her cancer. She celebrated by ringing the cancer center’s bell, a significant milestone in her journey.

However, Melissa’s joy was short-lived. In early 2024, a small cancerous lymph node was detected, leading her to resume treatment with chemotherapy and Opdivo, a different immunotherapy. The side effects, including severe pain and weight gain, were intense, but she continued to fight. After several rounds of treatment, another scan showed no evidence of disease. Yet, in August 2024, her Pet scan revealed another recurrence, requiring further treatments. She likens her cancer battle to a game of “whack-a-mole.”

Despite the physical and emotional toll, Melissa remains resilient, supported by her medical team and faith. She credits her Christian doctors, who prayed with her before procedures, for their compassionate care. Now, Melissa continues treatment, grateful for her improved quality of life, and cherishing every day as a gift.


  • Name:
    • Melissa W.
  • Diagnosis:
    • Gastric adenocarcinoma (stomach cancer)
  • Staging:
    • Stage 4b
  • Initial Symptoms:
    • Feeling like something was in her throat
    • Occasional nausea
    • Acid reflux
    • Occasional feeling of having boiling water in her stomach
    • Soreness in the bottom of her ribcage
  • Treatment:
    • Chemotherapy (FOLFOX)
    • Immunotherapy (zimberelimab, domvanalimab, Opdivo)

This interview has been edited for clarity. This is not medical advice. Please consult with your healthcare provider for treatment decisions.


Thank you for sharing your story, Melissa!

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Categories
Chemotherapy Colon Colorectal FOLFOX (folinic acid, fluorouracil, oxaliplatin) Patient Stories Treatments

Casandra’s Stage 4 Colon Cancer Story

Casandra’s Stage 4 Colon Cancer Story

Interviewed by: Taylor Scheib
Edited by: Chris Sanchez

Casandra, from Huntsville, UT, was recently diagnosed with stage 4 colon cancer that has spread to her liver and lung. She shares her story, starting with how she initially noticed rectal bleeding and pain in 2018, which she attributed to hemorrhoids. As time passed, she underwent gastric sleeve surgery and saw an improvement in her health, particularly due to her battle with interstitial cystitis of the bladder. However, by early 2024, she began to experience extreme fatigue and bowel irregularities, which she continued to ignore, thinking it was related to her chronic illness.

By August, Casandra’s symptoms had worsened, and she contacted a specialist, leading to a referral to a gastrointestinal doctor. A colonoscopy revealed a concerning tumor, and within days, she was diagnosed with invasive adenocarcinoma, a common form of colon cancer, which had spread to her liver and lung. Given the advanced stage of the tumor, surgery wasn’t an immediate option, and her medical team recommended aggressive chemotherapy (FOLFOX) with the hope of shrinking the tumor enough for future surgical removal.

Casandra describes her emotional journey following the diagnosis as surreal. It hit her hardest when she informed her father, expressing her fears. Over the past month, she has struggled with fear and confusion, but has also found moments of peace, thanks to the support of friends, family, and the wider cancer community.

Regarding treatment, Casandra receives chemotherapy every 2 weeks, followed by a 48-hour home infusion via a pump. This treatment is taxing, with significant side effects such as nausea, fatigue, cold sensitivity, and muscle spasms. After noticing her hair thinning, she made the decision to shave her head, which brought her relief.

Mentally, Casandra acknowledges that previous therapy she underwent to improve her mental health has helped her cope with her cancer diagnosis. She emphasizes the importance of taking breaks from cancer and finding moments of joy with her family. She shares that her biggest support system has come from her family, particularly her husband and daughter, as well as from connecting with other cancer patients through social media.

Casandra offers advice to others, urging them to trust their bodies and find doctors they can talk to comfortably. She emphasizes the importance of early detection and sharing her story to help others avoid the same oversight. Despite the challenges that lie ahead of her, she remains hopeful, buoyed by her support system and her determination to fight for herself and her family.


  • Name:
    • Casandra C.
  • Diagnosis:
    • Colon cancer
  • Staging:
    • Stage 4
  • Initial Symptoms:
    • Rectal bleeding
    • Extreme fatigue
    • Severe loss in appetite
    • Excessive pain in new areas
    • Changes in bowel habits
  • Treatment:
    • Chemotherapy (FOLFOX)

This interview has been edited for clarity. This is not medical advice. Please consult with your healthcare provider for treatment decisions.


Thank you for sharing your story, Casandra!

Inspired by Casandra's story?

Share your story, too!


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Symptoms: Blood in stool, changes in bowel habits, feeling gassy/bloated

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Symptoms: Severe stomach cramps, diarrhea, vomiting, anemia (discovered later)

Treatments: Surgery (hemicolectomy), chemotherapy