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Chemotherapy Domvanalimab fluorouracil 5fu FOLFOX (folinic acid, fluorouracil, oxaliplatin) Immunotherapy nivolumab (Opdivo) Patient Stories Stomach Cancer Treatments Zimberelimab

Melissa’s Stage 4B Stomach Cancer Story

Melissa W., Gastric Adenocarcinoma, Stage 4B

Initial Symptoms: Feeling like something was in her throat; occasional nausea; acid reflux; occasional feeling of having boiling water in her stomach; soreness in the bottom of her ribcage
Treatment: Chemotherapy (FOLFOX); immunotherapy (zimberelimab, domvanalimab, Opdivo)

Melissa’s Stage 4B Stomach Cancer Story

Interviewed by: Nikki Murphy
Edited by: Chris Sanchez

Melissa, a resident of Clarksville, TN, was diagnosed with stage 4b metastatic gastric adenocarcinoma, a form of stomach cancer, following a challenging diagnostic process that began in late 2021. After a mild case of COVID-19, she experienced persistent throat discomfort, but initial visits to specialists yielded no conclusive results. Doctors initially attributed her symptoms to acid reflux and anxiety. In September 2022, while vacationing in Mexico, Melissa experienced nausea and vomiting, but she dismissed it, believing it was a urinary tract infection.

Upon Melissa’s return home, her massage therapist noticed something unusual in her back, prompting her to seek further medical evaluation. A proactive primary care physician ordered an ultrasound, revealing gallstones, and Melissa underwent gallbladder surgery. Although she initially felt better, nausea returned, and an endoscopy revealed a paralyzed stomach and, ultimately, a mass near her esophagus. Biopsies confirmed that Melissa had invasive adenocarcinoma, a diagnosis that left her and her family in shock.

In December 2021, Melissa began treatment with FOLFOX chemotherapy and two trial immunotherapy drugs, zimberelimab and domvanalimab. Despite an initial prognosis that gave her less than a year to live, Melissa responded remarkably well to treatment. By April 2023, her scans showed no evidence of disease, an unexpected outcome given the aggressive nature of her cancer. She celebrated by ringing the cancer center’s bell, a significant milestone in her journey.

However, Melissa’s joy was short-lived. In early 2024, a small cancerous lymph node was detected, leading her to resume treatment with chemotherapy and Opdivo, a different immunotherapy. The side effects, including severe pain and weight gain, were intense, but she continued to fight. After several rounds of treatment, another scan showed no evidence of disease. Yet, in August 2024, her Pet scan revealed another recurrence, requiring further treatments. She likens her cancer battle to a game of “whack-a-mole.”

Despite the physical and emotional toll, Melissa remains resilient, supported by her medical team and faith. She credits her Christian doctors, who prayed with her before procedures, for their compassionate care. Now, Melissa continues treatment, grateful for her improved quality of life, and cherishing every day as a gift.


  • Name:
    • Melissa W.
  • Diagnosis:
    • Gastric adenocarcinoma (stomach cancer)
  • Staging:
    • Stage 4b
  • Initial Symptoms:
    • Feeling like something was in her throat
    • Occasional nausea
    • Acid reflux
    • Occasional feeling of having boiling water in her stomach
    • Soreness in the bottom of her ribcage
  • Treatment:
    • Chemotherapy (FOLFOX)
    • Immunotherapy (zimberelimab, domvanalimab, Opdivo)

This interview has been edited for clarity. This is not medical advice. Please consult with your healthcare provider for treatment decisions.


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