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Appendix Cancer Chemotherapy FOLFIRI (folinic acid, fluorouracil, irinotecan) FOLFOX (folinic acid, fluorouracil, oxaliplatin) Hysterectomy (radical) Patient Stories PIPAC (pressurized intraperitoneal aerosol chemotherapy) Surgery Treatments

Ariel’s Stage 4 High-Grade Appendix Cancer Story

Ariel M., Appendix Cancer, Stage 4, High-Grade

Symptom: Sharp pain with gas & bowel movements
Treatment: Radical hysterectomy, chemotherapy (FOLFOX & FOLFIRI), PIPAC clinical trial (pressurized intraperitoneal aerosol chemotherapy)

Ariel’s Stage 4 High-Grade Appendix Cancer Story

Interviewed by: Taylor Scheib
Edited by: Katrina Villareal

Ariel, a fitness professional and single mother to an 18-month-old son, was diagnosed with stage 4 high-grade appendix cancer at age 30. Her symptoms began as sharp pains with gas and bowel movements, which she initially dismissed as menstrual-related. A routine OB-GYN visit revealed a large mass, leading to a diagnosis of mucinous adenocarcinoma, a rare and aggressive appendix cancer that had spread to multiple organs.

Ariel underwent a radical hysterectomy, which was one of the most challenging aspects of her journey, ending her ability to have more children. She found this loss deeply difficult and struggled with grief. However, she found gratitude in her role as a mother and the perspective gained through her experience, and found strength by focusing on the present and embracing her emotions.

Ariel went through 25 rounds of chemotherapy (FOLFOX and FOLFIRI) but unsuccessfully qualified for HIPEC (hyperthermic intraperitoneal chemotherapy). She participated in a clinical trial for PIPAC (pressurized intraperitoneal aerosol chemotherapy) at City of Hope, which led to two negative biopsies. To access specialized care, Ariel and her family relocated to be near the Huntsman Cancer Institute. This move provided her with crucial care and an integrated healthcare system.

Ariel encourages others to take control of their health care, actively participate in treatment decisions, and interview doctors to ensure comfort with their care team. She also stresses the importance of asking for help, staying flexible in beliefs, and giving freely to others as part of the healing process.


  • Name: Ariel M.
  • Age at Diagnosis:
    • 30
  • Diagnosis:
    • High-Grade Appendix Cancer
  • Staging:
    • Stage 4
  • Initial Symptom:
    • Sharp pain with gas & bowel movements
  • Treatment:
    • Radical hysterectomy
    • Chemotherapy: FOLFOX & FOLFIRI
    • Clinical trial: PIPAC (pressurized intraperitoneal aerosol chemotherapy)
Ariel M.
Ariel M.
Ariel M.
Ariel M.
Ariel M.
Ariel M.
Ariel M.

This interview has been edited for clarity. This is not medical advice. Please consult with your healthcare provider for treatment decisions.


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Alli M., Appendix Cancer, Stage 4



Symptom: Severe abdominal pain
Treatments: Surgery (right hemisphere colectomy, appendectomy, HIPEC), chemotherapy (adjuvant chemo in 2014; after recurrence, 6 rounds of oxaliplatin with bevacizumab & capecitabine)

Ariel M., Appendix Cancer, Stage 4, High-Grade



Symptom: Sharp pain with gas & bowel movements

Treatment: Radical hysterectomy, chemotherapy (FOLFOX & FOLFIRI), PIPAC clinical trial (pressurized intraperitoneal aerosol chemotherapy)

Hannah R., Appendix Cancer, Stage 4



Symptoms: Bloating; fullness; UTIs; blood in urine; painful intercourse; high blood pressure; spotting
Treatment:Surgery (appendectomy, cytoreductive surgery); chemotherapy (FOLFOX, HIPEC); radiation to treat recurrence

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